Agni and Vyayama: Integrating Ayurvedic Metabolic Concepts with Modern Exercise Science, Epigenetic Evidence, and Translational Health Applications – A Review Article
Keywords:
Agni, Vyayama, Ayurveda, Metabolism, Gutmicrobiota, Epigenetics, DNA methylationAbstract
This review integrates classical Ayurvedic concepts of Agni (digestive and metabolic fire) and Vyayama (exercise) with contemporary biomedical research on metabolism, gut microbiota, and exercise-induced epigenetic modifications. The Jatharagni, Dhatvagni, and Bhutagni of classical texts are correlated with modern gastrointestinal physiology, tissue enzymatic activity, and energy metabolism. Recent studies demonstrate that physical exercise enhances gut microbial diversity, modulates DNA methylation patterns in metabolic and structural genes, and is associated with slower epigenetic aging, providing mechanistic support for Ayurvedic claims that properly dosed Vyayama kindles Agni, reduces Ama (toxic metabolic residues), and promotes Ojas (vital resilience). The review proposes an integrative "Agni index" incorporating clinical, microbial, metabolic, and epigenetic markers, and outlines future applications in personalized Vyayama prescription and preventive medicine for cardiometabolic and age-related disorders.
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