Role of Mahapaishachik Ghrita In Attention Deficit Hyperactivity Disorder- A case study
DOI:
https://doi.org/10.52482/ayurline.v10i06.1132Keywords:
Mahapaishachika Ghrita, Attention-Deficit Hyperactivity Disorder, DSM-5, Medhya Rasayana, Neurodevelopmental Disorder, UnmadaAbstract
Background: Attention-deficit hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder marked by persistent inattention, hyperactivity, and impulsivity, affecting academic, social, and daily functioning. Despite conventional treatment options, interest in complementary approaches has increased. Ayurveda correlates ADHD features with Unmada, involving Dosha imbalance and impairment of cognitive and behavioural functions. This case report evaluates the clinical effect of Mahapaishachika Ghrita on ADHD symptoms.
Case Details: An 8-year-old male presented with poor attention, excessive motor activity, and impulsive behaviour since early childhood. Clinical evaluation confirmed ADHD according to DSM-5 criteria. Ayurvedic assessment indicated Vata-Pitta predominance. Mahapaishachika Ghrita was administered for 60 days along with dietary modifications and regular parental counselling. Clinical assessment was conducted at baseline and on days 15, 30, 45, and 60.
Results: At baseline, the child fulfilled 7 of 9 DSM-5 criteria in both inattention and hyperactivity-impulsivity domains. Following 60 days of intervention, improvement was observed in attention span, hyperactivity, impulse control, and behavioural regulation. Better academic participation and social interaction were also reported. No adverse effects were noted during treatment.
Conclusion: Mahapaishachika Ghrita, administered with dietary modifications and parental counselling, may help reduce key ADHD manifestations, including inattention, hyperactivity, and impulsivity. The observed response suggests a potential supportive role for Ayurvedic Medhya Rasayana therapy in holistic management of childhood neurodevelopmental disorders. Larger controlled studies are required to establish its efficacy and safety.
References
1. Salari N, Ghasemi H, Abdoli N, Rahmani A, Shiri MH, Hashemian AH, et al. The global prevalence of ADHD in children and adolescents: a systematic review and meta-analysis. Ital J Pediatr. 2023;49:48. Doi:10.1186/s13052-023-01456-1.
2. [Internet]. ResearchGate. Available from: https://www.researchgate.net/publication/284530833
3. Cortese S. Pharmacologic treatment of attention-deficit/hyperactivity disorder. N Engl J Med. 2020;383(11):1050-1056.
4. Sharma PV, editor. Charaka Samhita. Sutrasthana, Chapter 1, Verse 55. Reprint ed. Varanasi: Chaukhambha Orientalia; 2008. P. 7.
5. Agnivesha. Charaka Samhita with Ayurveda Dipika commentary of Chakrapanidatta. Acharya YT, editor. Nidanasthana, Chapter 7. Varanasi: Chaukhambha Surbharati Prakashan; 2017.
6. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC: medicinal herb. J Pharmacogn Phytochem. 2015;3(5):102-106.
7. Katzenschlager R, Evans A, Manson A, Patsalos PN, Ratnaraj N, Watt H, et al. Mucuna pruriens in Parkinson’s disease: a double blind clinical and pharmacological study. J Neurol Neurosurg Psychiatry. 2004;75:1672-1677.
8. Chaudhari KS, Tiwari NR, Tiwari RR, Sharma RS. Neurocognitive effect of nootropic drug Brahmi (Bacopa monnieri) in Alzheimer’s disease. Ann Neurosci. 2017;24(2):111-122. Doi:10.1159/000475900.
9. Kour G, Sharma AK, Dash S, Bal N. Vacha (Acorus calamus Linn.): a valuable medicinal plant. Int J Ayur Pharma Res. 2014;2(8):1-11.
10. Wood JD. Neuropathophysiology of functional gastrointestinal disorders. World J Gastroenterol. 2007;13:1313-1332. Doi:10.3748/wjg.v13.i9.1313.
11. O’Mahony SM, Hyland NP, Dinan TG, Cryan JF. Maternal separation as a model of brain-gut axis dysfunction. Psychopharmacology. 2011;214:71-88. Doi:10.1007/S00213-010-2010-9.
12. Liang S, Wu X, Hu X, Wang T, Jin F. Recognizing depression from the microbiota-gut-brain axis. Int J Mol Sci. 2018;19:1592. Doi:10.3390/ijms19061592.
13. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington (VA): American Psychiatric Publishing; 2013.
14. Ghai OP, Paul VK, Bagga A. Essential pediatrics. 8th ed. New Delhi: CBS Publishers & Distributors; 2013. P. 720.
15. Tripathi B, editor. Ashtanga Hridaya of Vagbhata. Sutrasthana, Chapter 13, Verse 39. Reprint ed. Varanasi: Chaukhambha Sanskrit Pratishthan; 2017. P. 190.
16. Sarangdhara. Sarangdhara Samhita. Uttara Khanda, Snehapanavidhi Adhyaya. Tripathi I, editor. 5th ed. Varanasi: Chaukhambha Surbharati Prakashan; 2005. P. 320.
17. Shastri AD, editor. Bhaishajya Ratnavali with Vidyotini Hindi commentary. Varanasi: Chaukhambha Sanskrit Sansthan; p. 367.
18. Shastry JLN. Dravyaguna Sutramala. 1st ed. Varanasi: Chaukhambha Orientalia; 2005. P. 33.
19. Shastry JLN. Dravyaguna Sutramala. 1st ed. Varanasi: Chaukhambha Orientalia; 2005. P. 83.
20. Dash B, editor. Madanapala Nighantu. Abhayadi Varga, Verses 161-163. 1st ed. New Delhi: Health Harmony, B Jain Publishers; 2008. P. 56.
21. Dash B, editor. Madanapala Nighantu. Abhayadi Varga, Verses 161-163. 1st ed. New Delhi: Health Harmony, B Jain Publishers; 2008. P. 56.
22. Shastry JLN. Dravyaguna Sutramala. 1st ed. Varanasi: Chaukhambha Orientalia; 2005. P. 23.
23. Shastry JLN. Dravyaguna Sutramala. 1st ed. Varanasi: Chaukhambha Orientalia; 2005. P. 33.
24. Shastry JLN. Dravyaguna Sutramala. 1st ed. Varanasi: Chaukhambha Orientalia; 2005. P. 13.
25. Bhavamishra. Bhavaprakasha Nighantu. Haritakyadi Varga. Sitaram B, editor. Vol. 1. Varanasi: Chaukhambha Orientalia; 2006. P. 150-151.
26. Bhavamishra. Bhavaprakasha Nighantu. Guduchyadi Varga. Sitaram B, editor. Vol. 1. Varanasi: Chaukhambha Orientalia; 2006. P. 294.
27. Shastry JLN. Dravyaguna Sutramala. 1st ed. Varanasi: Chaukhambha Orientalia; 2005. P. 34.
28. Dash B, editor. Madanapala Nighantu. Abhayadi Varga, Verses 74-75. 1st ed. New Delhi: Health Harmony, B Jain Publishers; 2008. P. 25.
29. Sharma PV. Dravyaguna Vijnana. Vol. 2. Reprint ed. Varanasi: Chaukhambha Bharati Academy; 2001. P. 34.
30. Bhavamishra. Bhavaprakasha Nighantu. Haritakyadi Varga. Sitaram B, editor. Vol. 1. Varanasi: Chaukhambha Orientalia; 2006. P. 161.
31. Bhavamishra. Bhavaprakasha Nighantu. Karpuradi Varga. Sitaram B, editor. Vol. 1. Varanasi: Chaukhambha Orientalia; 2006. P. 209.
32. Agnivesha. Charaka Samhita with Ayurveda Dipika commentary of Chakrapanidatta. Acharya YT, editor. Chikitsasthana, Chapter 9. Varanasi: Chaukhambha Surbharati Prakashan; 2017.
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