Main Article Content
It is always said that childhood period is like a mirror, which reflects in after life the images first presented to it. When debility is considered particularly in children, near about quarter of chronic childhood disorders are neurological in origin. Cerebral Palsy is defined as a non- progressive disturbances in the developing fetal or infant brain which is accompanied by disturbances of sensation, perception, cognition, communication, behaviour as well as by epilepsy and secondary musculoskeletal problems. In modern medicine, there is only symptomatic treatment for neuro-motor disability but actually there is no effective treatment has been formulated at present which can totally cure this disorder. Hence, there is a need for the development of a well-planned ayurvedic approach in present era. So, we are proposing Sariva (Hemidesmus indicus R.Br.) as best choice in cerebral palsy. Sariva possesses madhur and Tikta rasa, Madhura vipaka, Sheeta veerya and Guru, Snigdha guna. Acharya Sushruta in Garbhinivyakaranasharir adhyaya has mentioned that on first day of Nalchhedana, the child should be sprinkled with cold water and then Madhu and Ghrita mixed with Ananata (Sariva) choorna should be given in small quantity three times in a day. It helps in promoting general and healthy growth, strength and intellect of children. It is also used in treating the conditions like Pangu, Mooka, Ashruti and Jada. In this article we have try to discuss about the pharmacokinetic of Sariva w. s. r. to cerebral palsy in children.
This work is licensed under a Creative Commons Attribution 4.0 International License.
2. Incidence of Cerebral Palsy Remains Constant in India 74912-1.htm, www.medindianet.com
3. Behraman, Kliegman, Jenson “Nelson textbook of paediatrics”, 17th edition; reprint
4. 2006; p. 2024.
5. Bax M, Tydeman C, Flodmark O, Clinical and MRI correlates of cerebral palsy: The European cerebral palsy study. JAMA 296 (2006): 1602–1608.
6. Nelson KB Causative factors in cerebral palsy; Clin Obstet Gynecol 51: 749–762.
7. Kaviraj Ambika Dutta Shastri, Sushruta Samhita, Part1, reprinted 2013 Varanasi: Chaukhambha Sanskrita Sansthana, Sutrasthana, 24/4-8, p.129130.
8. Ste´ phane Marret, Catherine vanhulle, and Annie laquerriere; Pathophysiology of cerebral palsy, Handbook of Clinical Neurology, Vol. 111 (3rd series) Paediatric Neurology Part I O. Dulac, M. Lassonde, and H.B. Sarnat, Editor © 2013 Elsevier B.V.
9. Nelson K.B., Causative factors in cerebral palsy; Clin Obstet Gynecol 51 (2008): 749– 762.
10. Pharoah P.O., Prevalence and pathogenesis of congenital anomalies in cerebral palsy; Arch Dis Child 92 (2007): 489-493.
11. Kirton A, de Veber G, Advances in perinatal ischemic stroke; Pediatr Neurol 40 (2009): 205–214.
12. Gibson C.S., Mc Lennan A.H., and Goldwater P.N., Antenatal causes of cerebral palsy: associations between inherited thrombophilias, viral and bacterial infection, and inherited susceptibility to infection; Obstet Gynecol Surv 58 (2003): 209–220.
13. Strijbis EM, Oudman I, van Essen P, Cerebral palsy and the application of the International criteria for acute intrapartum hypoxia; Obstet Gynecol 107 (2006): 1357– 1365.
14. Als H, Gilkerson L, Duffy F.H., A three-center, randomized, controlled trial of individualized developmental care for very low birth weight preterm infants: medical, neurodevelopmental, parenting, and caregiving effects; Dev Behav Pediatr 24 (2003): 399–408.
15. Choi, D.W.,; Ionic dependence of Glutamate neurotoxicity; J. Neurosci. (1987), 7: 369- 379.
16. Ankarcrona, M., J. M. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S. A. Lipton and P. Nicotera, Glutamate-induced neuronal death: a succession of nicrosis or apoptosis depending on mitochondrial function; Neuron, 15 (1995): 961-973.
17. Ban, J.Y., S.O. Cho, S. B. Koh, K.S. Song, K.Bae and Y.H.Seong, Protection of amyloid beta protein(25-35)- induced neurotoxicity by methanol extract of Smilacis chinae rhizome inn cultured rat neurons; J. Ethnopharmacol (2006); 106: 230-237.
18. Sarter, M.F. and J.P. Bruno, 1994; Cognitive functions of cortical ACh: Lessons from studies on trans-synaptic modulation of activated efflux; Trends Neurosci; 17: 217-221.
19. D’Almeida, V.R. Camarini, L.A. Azzalis, V.B. Junqueira and E.A. Carlini, 1996; Cronic fenfluramie treatment of rats with different ages: Effects on brain oxidative stress- related parameters; J. Biochem. Toxicol, 11: 197-201.
20. Kaviraj Ambika Dutta Shastri, Sushruta Samhita, Part1, reprinted 2013 Varanasi: Chaukhambha Sanskrita Sansthana, Sharirasthana, 10/17, p.103.
21. Priyavrat Sharma, Namrupajanam; Chaukhaha Bharati Academy; Varanasi; p. 191.
22. Priyavrat Sharma, Dravyagunavigyana, volume 2, reprinted 2012; Chaukhaha Bharati Academy; Varanasi; p. 799.
23. Lalrinpuia, Manajit Bora, S.N. Upadhyay, Koyel Mukherjee, Jayram Hazra, pharmacological and therapeutic profile of Anantamula (Hemidesmus indicus (l.) R. Br.): a comprehensive review; International Journal of Ayurveda and Pharma Research (2017); Vol 5; Issue 11; 49-57.
24. D. Sivaraman, S. Shatha Kumar, P.Muralidhara and Haibur Rahman, Effect of Hemidesmus indicus on cerebral infarct ischemia – reperfusion injured rats by four vesslel occlusion method; Pharmacologia 3(4): 91-102, 2012.
25. M.N. Ravishankara, Neeta Shrivastava, Harish Padh and M. Rajani, Evaluation of antioxidant properties of root bark of Hemidesmus indicus R. Br. (Anantmul); Phyotomedicine(2002):vol.9: 153-160.