The role of Udumbara (Ficus racemosa Linn.) unripe fruit in agnidushti with reference to digestive system diseases.
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Abstract
Introduction: Ayurveda describe a healthy person is one who possesses equilibrium of Tridosha,13 types of Agni, and excretion of mala, to balance physical and mental state. Agnidushti leads to indigestion, colitis, diarrhoea, dysentery, nausea, vomiting, and metabolic disorders like diabetes, obesity. It’s every part is used in treatment. It is used in the form of whole fruit , swarasa, curna, ksheerapaaka, siddha oil, avaleha, khalaka. Interdisciplinary Researches shown its antioxidant, hepatoprotective, hypoglycaemic, Gastro protective activity.Methods: Literature search done in Ayurveda classical texts, nighantus , and medicinal databases. Modern scientific data through search engines like Google Scholar, PubMed, PubMed Central, Ayush Portal..Didcussion:In Ayurveda udumbara is stated as pramehahara, atisarahara, yonidoshahara, sandhanakara, and balya due its kashayarasa and sheeta guna.Figs of Udumbar contains primary metabolites , minerals and phytoconstituents. Polyphenolic antioxidants, including dietary plant lignin, modulate the gut–brain axis. Phenolic compounds may help prevent or slow the progression of neurodegenerative diseases like Alzheimer's and Parkinson's. Lupeol is possessing anticancer property against a few neoplasms leg, colorectal, lung, and liver.The flavonoids, alkaloids, phenolics, saponins, and terpenoids proven inhibiting activity of the alpha (α)-amylase and alpha (α)-glucosidase enzymes, and antimicrobial against (Staphylococcus and Bacillus ceresus ). It is used in Gastric ulcer.Conclusion: Udumbara will be cheapest, easily available nutrition to children, in pregnant woman, travellers, malnourished patients of Cancer, diabetes, HIV, Koch’s. The inhibiting ability of free radicals, α-amylase and α-glycosidase glycaemic enzymes can increase the probability of developing new dietary nutraceutical from Udumbara.
Key words – Udumbar, agnidushti, digestive system, metabolic disorder, polyphenols
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References
- 1) Dr. Ravi Prakash Sharma; A CONCEPTUAL REVIEW OF AGNI AND ITS ROLE IN DIGESTION AND METABOLISM.; DOI: https://doi.org/10.22159/prl.ijayush.v14i12.1643
- 2) Agrawal AK, Yadav CR, Meena MS. Physiological aspects of Agni. Ayu. 2010 Jul;31(3):395-8. Doi: 10.4103/0974-8520.77159. PMID: 22131747; PMCID: PMC3221079.
- 3) Dr. Rameshwar Lal, Dr Bhanupriya Choudhury, Dr. Praveen Kumar; A Review of Ayurvedic Concepts of Agni and Their Correlation with Digestive and Metabolic Disorders.; https://doi.org/10.53555/AJBR.v27i3S.5635
- 4)D. K. Awasthi, and Archana Dixit; Medical application of Ficus racemosa (gular) WJPMR, 2023, 9(4), 142-149.
- 5)Nilanjan Pahari,Subhabrota Majumdar,Dipanjan Karati,Rana Mazumder; Exploring the Pharmacognostic properties and pharmacological activities of phytocompounds present in Ficus racemosa linn.: A concise review . DOI:10.1016/j.prmcm.2022.100137
- 6) S.Jasrey Max Suila,et al; Untargeted NMR metabolomics analysis of Ficus racemosa fruit extracts and UHPLC-MS/MS-molecular networking analysis of the active extract. https://doi.org/10.1016/j.lwt.2025.117931
- 7) Gitesh Kishor Chaware, Vikas Kumar, Satish Kumar & Pankaj Kumar (2020) Bioactive Compounds, Pharmacological Activity and Food Application of Ficus racemosa: A Critical Review, International Journal of Fruit Science, 20:sup2, S969-S986,
- DOI: 10.1080/15538362.2020.1774467
- 8) Bhagaonkar P.Y., ChavanV.N., Kanerkar U.R.;Nutritional Potential of Ficus racemosa L.fruits; Bioscience Discovery-2014, Vol.5-11, pp.150-153
- 9) The Role of Diet in Self-Medication Among Chimpanzees in the Sonso and Kanyawara Communities, Uganda; DOI:10.1007/0-387-33505-6_7
- 10)Ahmed, F., & Urooj, A. (2010). Traditional uses, medicinal properties, and phytopharmacology of Ficus racemosa: A review. Pharmaceutical Biology, 48(6), 672–681. https://doi.org/10.3109/13880200903241861
- 11) Mishra V, Khan NU, Singhal KC. Potential antifilarial activity of fruit extracts of Ficus racemosa Linn. against Seteria Cervi in vitro. Indian J Exp Biol. 2005 Apr; 43(4):346-50.
- 12) R. Bhaskara Rao, K. Anupama, K.R.L. Anand Swaroop, T. Marquesan, Evaluation of anti-pyretic potential of Ficus racemosa bark; https://doi.org/10.1078/094471102321621340
- 13) Terminalia chebula and Ficus racemosa principles mediated repression of novel drug target Las R - the transcriptional regulator and its controlled virulence factors produced by multiple drug-resistant Pseudomonas aeruginosa - Biocompatible formulation against drug resistant bacteria. Microbe Pathog. 2020 Nov; 148:104412. Doi: 10.1016/j.micpath.2020.104412. PeHUB 2020 Aug 14. PMID: 32798672
- 14) Guiling Ma, Yanting Chen; Polyphenol supplementation benefits human health via gut
- microbiota: A systematic review via meta-analysis; https://doi.org/10.1016/j.jff.2020.103829
- 15) E. C. Faust and L. F. Thomen; Parasiticidal Properties of the Proteolytic Enzyme Ficin.;https://doi.org/10.3181/00379727-47-13181P
- 16) Dr. Kuldeep Jagdale, Dr. J J Phadake, Dr. Omkar Ingale; Anti-Inflammatory Potential of Udumbara (Ficus Racemosa)- A Review International Journal of All Research Education and Scientific Methods (IJARESM), ISSN: 2455-6211, Volume 12, Issue 10, October-2024,
- 17) Dr.Poornima C. Joshi1, Dr.G.S.Kulkarni , Dr.Shashdhar S. Sarawad; Evaluation of Anti-inflammatory activity of Udumbara phala (Ficus glomerata. Roxb) on Wistar albino rats., Dravya Guna B.V.V.S Ayurved Medical college Bagalkot.
- 18)Li RW, Myers SP, et al. (2004) A new anti-inflammatory glucoside from Ficus racemosa L. Planta med 70:421-426.
- 19) MPK food; Food;Volume 48, Issue 2, February 2010, Pages 704-709
- 20) Balu Kolar, Sri Dharmasthala Manjunatheshwara ; An Experimental Evaluation of Udumbara (Ficus glomerata Roxb.) Baala Phala And Twak with Special Reference to Its Gastric Ulcer Preventive Activity-A comparative Study; Dravya Guna Vigyana College of Ayurveda and Hospital, Kuthpady, Udupi. 2010
- 21)M.H. Alma et al.;Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats.J. Ethnopharmacol.(2008)
- 22)Rao Ch, Verma AR, Vijaykumar M, Rastogi SJ.; Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats. Ethnopharmacology 2008, 17(115(2):323
- 23) Yogesh Shripad Thorat, Prachet Prahlad Bagewadikar, Ganesh Mali, Khalid Konda, Rajesh Bhaskar Nawale, Avinash Hanumant Hosmani. In Situ Gelling Gastro-retentive Raft Containing Ficus racemosa Fruit Extract: A Promising Approach to Treat GERD. Research Journal of Pharmacy and Technology. 2023; 16(8):3951-6. Doi: 10.52711/0974-360X.2023.00650
- 24) Patel MV, Patel KB, Gupta SN. Effects of Ayurvedic treatment on forty-three patients of ulcerative colitis. Ayu. 2010 Oct;31(4):478-81. doi: 10.4103/0974-8520.82046. PMID: 22048543; PMCID: PMC3202252
- 25) Rajesh D., Saravanan R.1 and Sonia Studies on Ficus racemosa Fruit Extract: A Potent Antioxidant and Antibacterial Agent https://doi.org/10.33745/ijzi.2022.v08i02.079
- 26)Iram-Nizam,M.Mushfiq, antioxident activity of five different solvent extracts of edible fruits.; Oriental Pharmacy & experimental medicine; Sept.2012,12(3);189-1956))
- 27)In vitro and in vivo antioxidant properties and DNA damage protective activity of green fruit of Ficus glomerata.;Verma AR,Vijaykumar M,Rao CV, Mathela CS, Food Chem.and Toxicol.2010 Feb;48(2):704-9
- 28) Li RW, Myers SP, et al. (2004) A new anti-inflammatory glucoside from Ficus racemosa L. Planta med 70:421-426.
- 29) Arti R. Verma, M. Vijayakumar , Chandana V. Rao , Chandra S.Mathela; In vitro and in vivo antioxidant properties and DNA damage protective activity of green fruit of Ficus glomerata; https://doi.org/10.1016/j.fct.2009.11.052
- 30)A Choudhury,RJ Mandade,SH Patil,A Khan,PD Warke,KS Patil; Effect of Ficus glomerata fruit extract on various Biochemical Parameters in Alloxan- induced diabetic rats.; Research J.Pharmacognosy and Phytochemistry 2010;2(1): 82-84.
- 31)Rao Chv,Verma AR,Vijaykumar M,Rastogi SJ.; Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats. Ethnopharmacology 2008, 17(115(2):323
- 32)Deshmukh et al.; Hypoglycemic activity of petroleum ether extract of Ficus racemosa fruits in Alloxan-induced diabetic Mice.; pharmacogy online 2:504-515(2007)
- 33)A role of Ficus species in the management of diabetes mellitus: A review
- 2018, Journal of Ethnopharmacology
- 34)Muniyandi, K., Jagadeesan, G., George, B.P. et al. α-Glycosidase, α-amylase inhibition kinetics, in vitro gastro-intestinal digestion, and apoptosis inducing abilities of Ficus macrocarpa L. f. and Ficus racemosa L. fruit polysaccharides. Food Sci Biotechnology 31, 1717–1728 (2022). https://doi.org/10.1007/s10068-022-01162-4
- 35) P G Muralikrishna,B Duraiswamy,Nk Nair;In silico docking and in vitro enzyme inhibition activity of unripe fruits of Ficus racemosa linn.; 27Aug ,2019 https://www.researchgate.net/publication/335430654
- 36) Rani A, Zia-Ul-Sabah, Tabassum F, Sharma AK. Molecular interplay between phytoconstituents of Ficus Racemosa and neurodegenerative diseases. Eur J Neurosci. 2024 Apr;59(7):1833-1847. Doi: 10.1111/ejn.16250. Epub 2024 Jan 12. PMID: 38217338
- neurodegeneration. Indian J Pharmacol. 2015 Nov-Dec;47(6):610-5. doi: 10.4103/0253-7613.169579.PMCID: PMC4689013
- 38) Anu Rani, Zia-Ul-Sabah, Fauzia Tabassum, Sharma; Molecular interplay between phytoconstituents of Ficus Racemosa and neurodegenerative diseases , https://doi.org/10.1111/ejn.16250
- 39)M.Gupta, A. Roy; Phytochemical Characterization of Udumbara Phala Churna (Ficus racemosa) and Krishnamrittika (Black Soil) Using FTIR and HRLCMS:Implications in Heavy Menstrual Bleeding. :1July,2023 DOI:10.5281/zenodo.17197113
- 40)Mamta Baunthiyal, Preeti Semwal, and Sushmita Dwivedi; Haemostatic Potential of Medicinal Plants and their Phytochemicals.; https://doi.org/10.51220/jmr.v16i1.8
- 41) Sivakumar, Manimekalai I., Sivakumari,K,Ashok.K ; ANTICANCER EFFECT OF FIG FRUIT FICUS RACEMOSA EXTRACT AGAINST HUMAN HEPTOCELLAR CARCINOMA (HepG-2) CELL LINE ;2019 IJRAR March 2019, Volume 6, Issue 1
- 42) Identification of novel potent pancreatic lipase inhibitors from Ficus racemosa
- DOI:10.51248/. v41i1.528
- 43)Nilay D. Solanki, Kirti Vadi, Sandip Patel ;Alleviating effect of Ficus racemosa in high-fat-high-fructose diet-induced non-alcoholic fatty liver disease;doi:10.25259/IJPP_406_2020
- 44)Heroor s,Beknal AK,Mahurkar N; Immunomodulatory activity of methanolic extract of fruits and bark of Ficus racemosa Linn., in mice and on human neutrophils. Indian J Pharmacol.2013Mar-Apr;45(2):130-5.
- 45)IrfanY,Khan M.A.,Shivkumar H.; Effect of unripe fruit extract of Ficus glomerata Roxb., in CCl4 and Paracetamol-induced hepatotoxicity in rats. Pharmacology online 2:1-13(2011)
- 46) Natália Martins , Lillian Barros , Isabel C.F.R. Ferreira;In vivo antioxidant activity of phenolic compounds: Facts and gaps;https://doi.org/10.1016/j.tifs.2015.11.008Get rights and content
- 47)Teja Pavani A.,Sheela D.,Ramesh D.,Sirisha Goli D.Toxicity Studies and Phytochemical Screening of Ficus racemosa & Kalanchoe pinnata Pharmaceutical Science-Pharmacology. (2023). International Journal of Life Science and Pharma Research, 13(4), P52-P60. https://doi.org/10.22376/ijlpr.2023.13.4.P52-P60
- Bibliography:
- 1)Charak Samhita: edited by Jadavji Trikamji Acharya; Chau Khamba, Prakashan, Varanasi, -Edition reprint 2011, Reg.No. A-77539
- 2)Sushruta Samhita (Part 1,2, and 3), Chaukhambha Sur Bharati Prakashan, Varanasi, revised edition 2009.
- 3)Nighantu Ratnakar, Part-2: Bhishagvarya Krushnashastri Navare; Chaukhambha Sanskrit Pratishthan, Delhi, 1st edition 2011.
- 4)Dhanvantari Nighantu: Dr.Anantram Sharma Foreword by Acharya Priyavrat Sharma; reprint 2004, Chaukhamba Bharti Academy, ISBN 978909872-0-2,
- 5)Nighantu Ratnakar, Part-2: Bhishagvarya Krushnashastri Navare; Chaukhambha Sanskrit Pratishthan, Delhi, 1st edition 2011.
- 6)Ayurvedic Pharmacopoeia of India, Part-1, Volume-3: Government of India, Ministry of Health and family welfare, Department of Indian Systems of Medicine & Homeopathy, New Delhi, The Controller of Publications, Civil Lines, Delhi 110054, 1st Edition 2001.
- 7)Website: Pub med - Google Scholar - Elsevier – Research gate –Ayush portal- Database of Indian Medicinal plants-Shodhaganga, https://niimh.nic.in/ebooks/e-Nighantu/